Role of F-box WD Repeat Domain Containing 7 in Type 1 Diabetes
نویسندگان
چکیده
Type I diabetes (T1DM) is a chronic immune system disease characterized by the devastation or injury of ß-cells in Langerhans Island, resulting insulin deficiency and hyperglycemia. This study determines new marker F-box WD repeat domain containing 7 (FBXW7). One hundred twenty type 1 diabetic patients from three different places (central child hospital, Alkindi center for endocrinology, Children’s Education Hospital) Iraq during period (20 December 2021 to 25 March 2022) an age ranges (4-17) years. The patient group consisted being derived groups: one healthy (33) was included as patient, two (20) newly diagnosed T1DM (67) with treatment. quantitative enzyme-linked immunosorbent assay (ELISA) biochemical parameters were used quantify protein FBXW-7 levels. FBG, Cholesterol, Triglyceride, HDL, LDL, VLDL, HbA1c, GOT, GPT, Total Oxidant status, Antioxidant status measured through spectrophotometry. Serum levels considerably elevated noticeably (p-value = 0.00). In terms FBXW7 protein, there significant variation between therapy groups. There no compared positively correlated TG, cholesterol, negatively HDL group. According ROC analysis, cutoff value (1.9) (2.1) treatment Levels are DM patients. significantly but not when
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ژورنال
عنوان ژورنال: Ibn Al-Haitham Journal For Pure And Applied Science
سال: 2023
ISSN: ['2521-3407', '1609-4042']
DOI: https://doi.org/10.30526/36.3.3030